HRAS, 1-186aa, Human

Proteins, Recombinant
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Product Name HRAS, 1-186aa, Human
Applications SDS-PAGE
Background HRAS, also known as GTPase HRas, belongs to the Ras family which function in signal transduction pathways. This protein can bind GTP and GDP, and it has intrinsic GTPase activity. HRAS undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Defects in HRAS are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Recombinant human HRAS protein was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 200mM NaCl, 2mM DTT, 50% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 20.7kDa (190aa), confirmed by MALDI-TOF.
NCBI Accession # NP_001123914
Purity > 90% by SDS-PAGE
References McCormick F. (1995) Mol Reprod Dev. 42(4):500-6
Ayllon V. et al. (2000) Mol Membr Biol. 17(2):65-73
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms HMG14, GC104230, v-Ha-ras Harvey rat sarcoma viral oncogene homolog C BAS/HAS, c H ras, C HA RAS1, c has/bas p21 protein, c ras Ki 2 activated oncogene, CTLO, GTP and GDP binding peptide B, H Ras 1, H RASIDX, Ha Ras, Ha Ras1 proto oncoprotein, HAMSV, HRAS, HRAS1, K ras, N ras, p19 H RasIDX protein, p21ras, Ras family small GTP binding protein H Ras, RASH1, Transformation gene oncogene HAMSV, Transforming protein p21, v Ha ras Harvey rat sarcoma viral oncogene homolog, VH Ras, vHa RAS.

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