Human A Disintegrin And Metalloprotease 33 (ADAM33) ELISA Kit
| Product Name | Human A Disintegrin And Metalloprotease 33 (ADAM33) ELISA Kit |
|---|---|
| Description | ADAM33 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.The 813-amino acid human protein shares 70% identity with the mouse protein. ADAM33 has a domain organization identical to that of previously reported members of the ADAM family, and contains the typical zinc-binding consensus sequence in the metalloprotease domain and a pattern of cysteine localization in the EGF-like domain that is typical of an EGF-like motif. The human protein shows 44% identity with Xenopus ADAM13, 40% with human ADAM19 , and 39% with human ADAM12. This assay has high sensitivity and excellent specificity for detection of Human ADAM33. No significant cross-reactivity or interference between Human ADAM33 and analogues was observed. |
| Synonyms | RP5-964F7.2, C20orf153, DJ964F7.1, DKFZp434K0521, FLJ35308, FLJ36751, MGC149823, MGC71889, a disintegrin and metalloprotease 33|a disintegrin and metalloproteinase domain 33|disintegrin and reprolys |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.054 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | ADAM33 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.The 813-amino acid human protein shares 70% identity with the mouse protein. ADAM33 has a domain organization identical to that of previously reported members of the ADAM family, and contains the typical zinc-binding consensus sequence in the metalloprotease domain and a pattern of cysteine localization in the EGF-like domain that is typical of an EGF-like motif. The human protein shows 44% identity with Xenopus ADAM13, 40% with human ADAM19 , and 39% with human ADAM12. |
| Supplier | Abebio |
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