Human A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) ELISA Kit
| Product Name | Human A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) ELISA Kit |
|---|---|
| Description | The predicted 860-amino acid ADAMTS6 protein has a domain structure characteristic of ADAMTSs. Beginning at the N terminus, it has a preproregion containing a potential furin cleavage site and a putative cysteine-switch, a catalytic domain containing a typical reprolysin-type zinc-binding signature and a 'met turn,' a disintegrin-like domain, a conserved thrombospondin module, a cysteine-rich domain, a spacer domain, and a second, less conserved thrombospondin module. The mature ADAMTS6 protein has 2 potential N-linked glycosylation sites. Northern blot analysis of several human tissues detected an approximately 8.5-kb ADAMTS6 transcript that was expressed at low levels in placenta and at barely detectable levels in a number of other tissues. Adamts6 was not detectably expressed during mouse embryo development. This assay has high sensitivity and excellent specificity for detection of Human ADAMTS6. No significant cross-reactivity or interference between Human ADAMTS6 and analogues was observed. |
| Synonyms | ADAM-TS6, a disintegrin and metalloproteinase with thrombospondin motifs 6|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 |
| Method | Sandwich ELISA |
| Detection Range | 3.12-200 ng/mL |
| Sensitivity | 0.78 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | The predicted 860-amino acid ADAMTS6 protein has a domain structure characteristic of ADAMTSs. Beginning at the N terminus, it has a preproregion containing a potential furin cleavage site and a putative cysteine-switch, a catalytic domain containing a typical reprolysin-type zinc-binding signature and a 'met turn,' a disintegrin-like domain, a conserved thrombospondin module, a cysteine-rich domain, a spacer domain, and a second, less conserved thrombospondin module. The mature ADAMTS6 protein has 2 potential N-linked glycosylation sites. Northern blot analysis of several human tissues detected an approximately 8.5-kb ADAMTS6 transcript that was expressed at low levels in placenta and at barely detectable levels in a number of other tissues. Adamts6 was not detectably expressed during mouse embryo development. |
| Supplier | Abebio |
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