| Product Name | Human Adipocyte enhancer-binding protein 1 (AEBP1) ELISA Kit |
|---|---|
| Description | AEBP1 binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells. The deduced 1,158-amino acid ACLP protein contains a putative signal peptide; an 11-residue lys/pro-rich motif repeated 4 times in the N terminus; a domain with 30% identity to the slime mold adhesion protein discoidin I; and a C-terminal 500-amino acid domain with 39% identity to carboxypeptidase E (CPE). This assay has high sensitivity and excellent specificity for detection of Human AEBP1. No significant cross-reactivity or interference between Human AEBP1 and analogues was observed. |
| Synonyms | ACLP, FLJ33612, AE-binding protein 1|adipocyte enhancer binding protein 1|aortic carboxypeptidase-like protein |
| Method | Sandwich ELISA |
| Detection Range | 0.78-50 ng/mL |
| Sensitivity | 0.32 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | AEBP1 binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells. The deduced 1,158-amino acid ACLP protein contains a putative signal peptide; an 11-residue lys/pro-rich motif repeated 4 times in the N terminus; a domain with 30% identity to the slime mold adhesion protein discoidin I; and a C-terminal 500-amino acid domain with 39% identity to carboxypeptidase E (CPE). |
| Supplier | Abebio |
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