Human AF4/FMR2 family member 1 (AFF1) ELISA Kit

Category: Assay Kits
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AE24174HU
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Product Name Human AF4/FMR2 family member 1 (AFF1) ELISA Kit
Description The sequence of the complete open reading frame for this fusion transcript revealed that the MLL protein is homologous with DNA methyltransferase, the Drosophila trithorax gene product, and the 'AT-hook' motif of high mobility group proteins. An alternative splice that deletes the AT-hook region of MLL was identified. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant-negative mechanism in leukemogenesis. This gene is also symbolized MLLT2. This assay has high sensitivity and excellent specificity for detection of Human AFF1. No significant cross-reactivity or interference between Human AFF1 and analogues was observed.
Synonyms AF4, MGC134969, MLLT2, PBM1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 2|myeloid/lymphoid or mixed-lineage leukemia trithorax homolog 2|pre-B-cell
Method Sandwich ELISA
Detection Range 0.156-10 ng/mL
Sensitivity 0.059 ng/mL
Reactivity Human
Sample Types Serum, Plasma, Other biological fluids.
Supplier Abebio

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