| Product Name | Human Cerebellin-1 (CBLN1) ELISA Kit |
|---|---|
| Description | Precerebellin, or CBLN1, is the precursor of a conserved brain-specific hexadecapeptide termed cerebellin. CBLN1 and other members of the precerebellin family also contain a C-terminal C1q signature domain that mediates trimeric assembly of atypical collagen complexes. The deduced 193-amino acid protein contains a hydrophobic N terminus followed by the cerebellin sequence. It also contains 3 potential N-glycosylation sites. Over about 145 amino acids in its C terminus, CBLN1 shares 31.3% identity with C1QB , but it lacks N-terminal collagen-like motifs. The cerebellin peptide is flanked by val-arg and glu-pro residues, suggesting that it is not liberated from precerebellin by the classical dibasic amino acid proteolytic mechanism seen in many neuropeptide precursors. This assay has high sensitivity and excellent specificity for detection of Human CBLN1. No significant cross-reactivity or interference between Human CBLN1 and analogues was observed. |
| Synonyms | Cerebellin 1 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.054 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Precerebellin, or CBLN1, is the precursor of a conserved brain-specific hexadecapeptide termed cerebellin. CBLN1 and other members of the precerebellin family also contain a C-terminal C1q signature domain that mediates trimeric assembly of atypical collagen complexes. The deduced 193-amino acid protein contains a hydrophobic N terminus followed by the cerebellin sequence. It also contains 3 potential N-glycosylation sites. Over about 145 amino acids in its C terminus, CBLN1 shares 31.3% identity with C1QB , but it lacks N-terminal collagen-like motifs. The cerebellin peptide is flanked by val-arg and glu-pro residues, suggesting that it is not liberated from precerebellin by the classical dibasic amino acid proteolytic mechanism seen in many neuropeptide precursors. |
| Supplier | Abebio |
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