| Product Name | Human Cytoplasmic dynein 2 heavy chain 1 (DYNC2H1) ELISA Kit |
|---|---|
| Description | DYNC2H1 encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. The light intermediate chains, with molecular masses of 55 to 59 kD, are unique to cytoplasmic dynein and contain consensus ATPase elements. Both axonemal and cytoplasmic dyneins also contain light chains of 8 to 25 kD. This assay has high sensitivity and excellent specificity for detection of Human DYNC2H1. No significant cross-reactivity or interference between Human DYNC2H1 and analogues was observed. |
| Synonyms | ATD3, DHC1b, DHC2, DNCH2, DYH1B, FLJ11756, hdhc11, DYNC2H1 variant protein|cytoplasmic dynein 2 heavy chain|dynein heavy chain, isotype 1B|dynein, cytoplasmic, heavy chain-2|dynein, cytoplasmic, hea |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.124 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
DYNC2H1 encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. The light intermediate chains, with molecular masses of 55 to 59 kD, are unique to cytoplasmic dynein and contain consensus ATPase elements. Both axonemal and cytoplasmic dyneins also contain light chains of 8 to 25 kD. |
| Supplier | Abebio |
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