| Product Name | Human DnaJ homolog subfamily C member 13 (DNAJC13) ELISA Kit |
|---|---|
| Description | DNAJC13, Contains 1 J domain. DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s and can be categorized into three groups, depending on the presence of other domains. Six DnaJ homologs have been identified in Escherichia coli and 22 in Saccharomyces cerevisiae. Genome-wide analysis has revealed 41 DnaJ/Hsp40 family members in humans. This assay has high sensitivity and excellent specificity for detection of Human DNAJC13. No significant cross-reactivity or interference between Human DNAJC13 and analogues was observed. |
| Synonyms | FLJ25863, KIAA0678, RME8, DnaJ domain-containing protein RME-8 |
| Method | Sandwich ELISA |
| Detection Range | 0.78-50 ng/mL |
| Sensitivity | 0.33 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | DNAJC13, Contains 1 J domain. DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s and can be categorized into three groups, depending on the presence of other domains. Six DnaJ homologs have been identified in Escherichia coli and 22 in Saccharomyces cerevisiae. Genome-wide analysis has revealed 41 DnaJ/Hsp40 family members in humans. |
| Supplier | Abebio |
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