Human Dynein heavy chain domain-containing protein 1 (DNHD1) ELISA Kit
| Product Name | Human Dynein heavy chain domain-containing protein 1 (DNHD1) ELISA Kit |
|---|---|
| Description | DNHD1 Belongs to the dynein heavy chain family. Dynein was first isolated from Tetrahymena cilia four decades ago. The analysis of the primary structure of the dynein heavy chain and the discovery that many organisms express multiple dynein heavy chains have led to two insights. One, dynein, whose motor domain comprises six AAA modules and two potential mechanical levers, generates movement by a mechanism that is fundamentally different than that which underlies the motion of myosin and kinesin. And two, organisms with cilia or flagella express approximately 14 different dynein heavy chain genes, each gene encodes a distinct dynein protein isoform, and each isoform appears to be functionally specialized. Sequence comparisons demonstrate that functionally equivalent isoforms of dynein heavy chains are well conserved across species. This assay has high sensitivity and excellent specificity for detection of Human DNHD1. No significant cross-reactivity or interference between Human DNHD1 and analogues was observed. |
| Synonyms | C11orf47, CCDC35, DHCD1, DKFZp434G0812, DKFZp686J0796, DKFZp686N1238, DNHD1L, FLJ00251, FLJ32752, FLJ35709, FLJ39625, FLJ43897, FLJ46184, MGC133191, DNHD1 variant protein|coiled-coil domain containi |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.112 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | DNHD1 Belongs to the dynein heavy chain family. Dynein was first isolated from Tetrahymena cilia four decades ago. The analysis of the primary structure of the dynein heavy chain and the discovery that many organisms express multiple dynein heavy chains have led to two insights. One, dynein, whose motor domain comprises six AAA modules and two potential mechanical levers, generates movement by a mechanism that is fundamentally different than that which underlies the motion of myosin and kinesin. And two, organisms with cilia or flagella express approximately 14 different dynein heavy chain genes, each gene encodes a distinct dynein protein isoform, and each isoform appears to be functionally specialized. Sequence comparisons demonstrate that functionally equivalent isoforms of dynein heavy chains are well conserved across species. |
| Supplier | Abebio |
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