| Product Name | Human Excitatory amino acid transporter 5 (SLC1A7) ELISA Kit |
|---|---|
| Description | EAAT5-mediated L-glutamate uptake was sodium- and voltage-dependent and chloride-independent. Transporter currents elicited by glutamate were also sodium- and voltage-dependent, but ion substitution experiments suggested that this current was largely carried by chloride ions.Although EAAT5 shares the structural homologies of the EAAT family, 1 novel feature of the EAAT5 sequence is a C-terminal motif previously identified in N-methyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. EAAT5 has 46% amino acid sequence identity with EAAT1 (SLC1A3), 43% identity with EAAT4 (SLC1A6), 37% identity with EAAT3 (SLC1A1), and 36% identity with EAAT2 (SLC1A2). This assay has high sensitivity and excellent specificity for detection of Human SLC1A7. No significant cross-reactivity or interference between Human SLC1A7 and analogues was observed. |
| Synonyms | AAAT, EAAT5, FLJ36602, excitatory amino acid transporter 5 (retinal glutamate transporter) |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.122 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | EAAT5-mediated L-glutamate uptake was sodium- and voltage-dependent and chloride-independent. Transporter currents elicited by glutamate were also sodium- and voltage-dependent, but ion substitution experiments suggested that this current was largely carried by chloride ions.Although EAAT5 shares the structural homologies of the EAAT family, 1 novel feature of the EAAT5 sequence is a C-terminal motif previously identified in N-methyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. EAAT5 has 46% amino acid sequence identity with EAAT1 (SLC1A3), 43% identity with EAAT4 (SLC1A6), 37% identity with EAAT3 (SLC1A1), and 36% identity with EAAT2 (SLC1A2). |
| Supplier | Abebio |
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