Human Histone-lysine N-methyltransferase PRDM9 (PRDM9) ELISA Kit
| Product Name | Human Histone-lysine N-methyltransferase PRDM9 (PRDM9) ELISA Kit |
|---|---|
| Description | The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation. The deduced 862-amino acid Meisetz protein contains a PR/SET domain in its N-terminal portion and a zinc finger domain containing multiple C2H2-type zinc fingers in its C-terminal portion. Hayashi et al. (2005) also cloned 2 Meisetz splice variants that encode shorter isoforms lacking the zinc finger domain. The PR/SET domain of Meisetz is highly conserved in human PRDM9. In situ hybridization, RT-PCR, and Northern blot analysis showed that mouse Meisetz transcripts were only expressed in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis. This assay has high sensitivity and excellent specificity for detection of Human PRDM9. No significant cross-reactivity or interference between Human PRDM9 and analogues was observed. |
| Synonyms | PFM6, PR-domain containing protein 9 |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation. The deduced 862-amino acid Meisetz protein contains a PR/SET domain in its N-terminal portion and a zinc finger domain containing multiple C2H2-type zinc fingers in its C-terminal portion. Hayashi et al. (2005) also cloned 2 Meisetz splice variants that encode shorter isoforms lacking the zinc finger domain. The PR/SET domain of Meisetz is highly conserved in human PRDM9. In situ hybridization, RT-PCR, and Northern blot analysis showed that mouse Meisetz transcripts were only expressed in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis. |
| Supplier | Abebio |
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