Human Histone-lysine N-methyltransferase SETD7 (SETD7) ELISA Kit
| Product Name | Human Histone-lysine N-methyltransferase SETD7 (SETD7) ELISA Kit |
|---|---|
| Description | Methylation of histone H3 at lysine-9 (K9) by SUV39H1 and the subsequent recruitment of heterochromatin protein-1 (HP1) is linked to gene silencing. In addition to K9, H3 methylation also occurs at K4, K27, and K36. SET7 methylates H3-K4 in vitro and in vivo and that methylation of H3-K4 and methylation of H3-K9 inhibit each other. Furthermore, H3-K4 methylation and H3-K9 methylation by SET7 and SUV39H1, respectively, were found to have differential effects on subsequent histone acetylation by p300. This study provided a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription.Set9 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site. This assay has high sensitivity and excellent specificity for detection of Human SETD7. No significant cross-reactivity or interference between Human SETD7 and analogues was observed. |
| Synonyms | FLJ21193, KIAA1717, KMT7, SET7, SET7/9, SET9, H3-K4-HMTase|SET domain-containing protein 7|histone H3-K4 methyltransferase|histone H3-lysine 4-specific methyltransferase |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.054 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Methylation of histone H3 at lysine-9 (K9) by SUV39H1 and the subsequent recruitment of heterochromatin protein-1 (HP1) is linked to gene silencing. In addition to K9, H3 methylation also occurs at K4, K27, and K36. SET7 methylates H3-K4 in vitro and in vivo and that methylation of H3-K4 and methylation of H3-K9 inhibit each other. Furthermore, H3-K4 methylation and H3-K9 methylation by SET7 and SUV39H1, respectively, were found to have differential effects on subsequent histone acetylation by p300. This study provided a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription.Set9 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site. |
| Supplier | Abebio |
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