Human Leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5) ELISA Kit
| Product Name | Human Leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5) ELISA Kit |
|---|---|
| Description | Leukocyte immunoglobulin-like receptor subfamily B member 4is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. This assay has high sensitivity and excellent specificity for detection of Human LILRB5. No significant cross-reactivity or interference between Human LILRB5 and analogues was observed. |
| Synonyms | XXbac-BCX105G6.10, CD85C, LIR-8, LIR8, leukocyte immunoglobulin-like receptor 8|leukocyte immunoglobulin-like receptor, subfamily B, member 5 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.057 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Leukocyte immunoglobulin-like receptor subfamily B member 4is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. |
| Supplier | Abebio |
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