Human Mannan-binding lectin serine peptidase 2 (MASP2) ELISA Kit
| Product Name | Human Mannan-binding lectin serine peptidase 2 (MASP2) ELISA Kit |
|---|---|
| Description | MASP2 is a protein involved in the complement system. Mannose-binding lectin (MBL) is a serum component which participates in innate immunity by activating complement via a novel pathway. Human MBL forms complexes with two types of serine proteases termed MASP (MBL-associated serine protease). These two proteases, MASP1 and MASP2, are structurally similar to one another as well as to C1r and C1s. Together, MASP, C1r and C1s constitute a novel serine protease family. It is likely that human MASP1 is able to activate C3, while human MASP2 cleaves C4, although further functional studies are required to confirm this. Based on the analysis of MASP cDNA of vertebrates and ascidians, the MASP/C1r/C1s family can be classified into two groups. This assay has high sensitivity and excellent specificity for detection of Human MASP2. No significant cross-reactivity or interference between Human MASP2 and analogues was observed. |
| Synonyms | MAP19, MASP-2, sMAP, MBL-associated plasma protein of 19 kD|MBL-associated serine protease 2|mannan-binding lectin serine protease 2|small MBL-associated protein |
| Method | Sandwich ELISA |
| Detection Range | 31.25 -2000 pg/mL |
| Sensitivity | 13.9 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | MASP2 is a protein involved in the complement system. Mannose-binding lectin (MBL) is a serum component which participates in innate immunity by activating complement via a novel pathway. Human MBL forms complexes with two types of serine proteases termed MASP (MBL-associated serine protease). These two proteases, MASP1 and MASP2, are structurally similar to one another as well as to C1r and C1s. Together, MASP, C1r and C1s constitute a novel serine protease family. It is likely that human MASP1 is able to activate C3, while human MASP2 cleaves C4, although further functional studies are required to confirm this. Based on the analysis of MASP cDNA of vertebrates and ascidians, the MASP/C1r/C1s family can be classified into two groups. |
| Supplier | Abebio |
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