Human Metastasis-associated in colon cancer protein 1 (MACC1) ELISA Kit
| Product Name | Human Metastasis-associated in colon cancer protein 1 (MACC1) ELISA Kit |
|---|---|
| Description | MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR, or MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.The deduced 852-amino acid has an SH3 domain, a proline-rich motif for binding SH3 domain-containing proteins, additional binding motifs for SH2 and SH3 domain-containing proteins, EPS15 homology domains, clathrin and retinoblastoma protein (RB1) interaction domains, and putative tyrosine phosphorylation sites. It shares about 44% identity with SH3BP4, and putative orthologs were identified in chicken, mouse, rat, dog, and chimp. This assay has high sensitivity and excellent specificity for detection of Human MACC1. No significant cross-reactivity or interference between Human MACC1 and analogues was observed. |
| Synonyms | 7A5, SH3BP4L, OTTHUMP00000201891|putative binding protein 7a5 |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.116 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR, or MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.The deduced 852-amino acid has an SH3 domain, a proline-rich motif for binding SH3 domain-containing proteins, additional binding motifs for SH2 and SH3 domain-containing proteins, EPS15 homology domains, clathrin and retinoblastoma protein (RB1) interaction domains, and putative tyrosine phosphorylation sites. It shares about 44% identity with SH3BP4, and putative orthologs were identified in chicken, mouse, rat, dog, and chimp. |
| Supplier | Abebio |
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