Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ELISA Kit
| Product Name | Human Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ELISA Kit |
|---|---|
| Description | Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is 1 of 3 orthologs of the yeast autophagosome protein Atg8. The deduced 147-amino acid protein shares 55% identity with rat Map1lc3. Northern blot analysis detected a 1.9-kb transcript expressed predominantly in placenta, lung, and ovary, with little to no expression in other tissues examined. Western blot analysis of transfected human embryonic kidney cells detected MAP1LC3C proteins of about 16 and 15.5 kD. MAP1LC3C underwent C-terminal cleavage after the conserved residue gly120. Gly120 was required for posttranslational modification of the MAP1LC3C protein. This assay has high sensitivity and excellent specificity for detection of Human MAP1LC3C. No significant cross-reactivity or interference between Human MAP1LC3C and analogues was observed. |
| Synonyms | LC3C, LC3-like protein 2|MAP1 light chain 3-like protein 2 |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is 1 of 3 orthologs of the yeast autophagosome protein Atg8. The deduced 147-amino acid protein shares 55% identity with rat Map1lc3. Northern blot analysis detected a 1.9-kb transcript expressed predominantly in placenta, lung, and ovary, with little to no expression in other tissues examined. Western blot analysis of transfected human embryonic kidney cells detected MAP1LC3C proteins of about 16 and 15.5 kD. MAP1LC3C underwent C-terminal cleavage after the conserved residue gly120. Gly120 was required for posttranslational modification of the MAP1LC3C protein. |
| Supplier | Abebio |
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