Human Mitochondrial import receptor subunit TOM70 (TOMM70A) ELISA Kit
| Product Name | Human Mitochondrial import receptor subunit TOM70 (TOMM70A) ELISA Kit |
|---|---|
| Description | The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.TOMM70A is 29% identical to the mitochondrial precursor protein import receptor of Neurospora crassa. RT-PCR analysis detected ubiquitous expression of KIAA0719, with relatively weak expression in pancreas, testis, and spleen.the cytosolic chaperones HSP90 and HSP70 dock onto a specialized tetratricopeptide domain in the import receptor TOMM70 at the outer mitochondrial membrane. This interaction served to deliver a set of preproteins to the receptor for subsequent membrane translocation dependent on the HSP90 ATPase. Disruption of the chaperone/TOMM70 recognition inhibited the import of these preproteins into mitochondria. This assay has high sensitivity and excellent specificity for detection of Human TOMM70A. No significant cross-reactivity or interference between Human TOMM70A and analogues was observed. |
| Synonyms | FLJ90470, translocase of outer mitochondrial membrane 70 homolog A |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.101 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.TOMM70A is 29% identical to the mitochondrial precursor protein import receptor of Neurospora crassa. RT-PCR analysis detected ubiquitous expression of KIAA0719, with relatively weak expression in pancreas, testis, and spleen.the cytosolic chaperones HSP90 and HSP70 dock onto a specialized tetratricopeptide domain in the import receptor TOMM70 at the outer mitochondrial membrane. This interaction served to deliver a set of preproteins to the receptor for subsequent membrane translocation dependent on the HSP90 ATPase. Disruption of the chaperone/TOMM70 recognition inhibited the import of these preproteins into mitochondria. |
| Supplier | Abebio |
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