Human Multidrug resistance-associated protein 7 (ABCC10) ELISA Kit
| Product Name | Human Multidrug resistance-associated protein 7 (ABCC10) ELISA Kit |
|---|---|
| Description | Members of the ABC family of membrane proteins, such as ABCC10, are involved in energy-dependent transport of a wide variety of substrates across membranes. The 1,492-amino acid ABCC10 protein has a calculated molecular mass of 162 kD. It contains 2 nucleotide-binding folds, 17 predicted transmembrane segments arranged in 3 transmembrane domains, and 3 predicted N-glycosylation sites. Northern blot analysis was unable to detected ABCC10 expression, but RT-PCR detected ABCC10 expression in all 10 tissues examined. In vitro-translated ABCC10 had an apparent molecular mass of 158 kD by SDS-PAGE.Basal MRP7 promoter activity relied upon a proximal segment of the 5-prime flanking region bearing an E2F site acting cooperatively with 2 closely positioned SP1 sites. This assay has high sensitivity and excellent specificity for detection of Human ABCC10. No significant cross-reactivity or interference between Human ABCC10 and analogues was observed. |
| Synonyms | RP5-895C5.1, EST182763, MRP7, SIMRP7, ATP-binding cassette, sub-family C, member 10|multidrug resistance-associated protein 7 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.061 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Members of the ABC family of membrane proteins, such as ABCC10, are involved in energy-dependent transport of a wide variety of substrates across membranes. The 1,492-amino acid ABCC10 protein has a calculated molecular mass of 162 kD. It contains 2 nucleotide-binding folds, 17 predicted transmembrane segments arranged in 3 transmembrane domains, and 3 predicted N-glycosylation sites. Northern blot analysis was unable to detected ABCC10 expression, but RT-PCR detected ABCC10 expression in all 10 tissues examined. In vitro-translated ABCC10 had an apparent molecular mass of 158 kD by SDS-PAGE.Basal MRP7 promoter activity relied upon a proximal segment of the 5-prime flanking region bearing an E2F site acting cooperatively with 2 closely positioned SP1 sites. |
| Supplier | Abebio |
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