Human Muscle Skeletal Receptor Tyrosine Kinase antibody (MUSK-Ab) ELISA Kit
| Product Name | Human Muscle Skeletal Receptor Tyrosine Kinase antibody (MUSK-Ab) ELISA Kit |
|---|---|
| Description | Human Muscle Skeletal Receptor Tyrosine Kinase antibody (MUSK-Ab) ELISA Kit has high sensitivity and excellent specificity for detection of Human MUSK-Ab. No significant cross-reactivity or interference between Human MUSK-Ab and analogues was observed. MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction. It is activated by a nerve-derived proteoglycan called agrin. This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK (Muscle specific kinase). MuSK is a receptor tyrosine kinase - meaning that it induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor.In mice which are deficient for either agrin or MuSK, the neuromuscular junction does not form. Many other proteins also comprise the NMJ, and are required to maintain its integrity. This Human Muscle Skeletal Receptor Tyrosine Kinase antibody (MUSK-Ab) ELISA Kit employs the competitive enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with an antibody specific to MUSK-Ab. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated MUSK-Ab and incubated. The competitive inhibition reaction is launched between with HRP labeled MUSK-Ab and unlabeled MUSK-Ab with the antibody. A substrate solution is added to the wells and the color develops in opposite to the amount of MUSK-Ab in the sample. The color development is stopped and the intensity of the color is measured. |
| Synonyms | MUSK-Ab |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Human |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Storage | 2-8°C |
| Background | MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction. It is activated by a nerve-derived proteoglycan called agrin. This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK (Muscle specific kinase). MuSK is a receptor tyrosine kinase - meaning that it induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor.In mice which are deficient for either agrin or MuSK, the neuromuscular junction does not form. Many other proteins also comprise the NMJ, and are required to maintain its integrity. |
| Supplier | Abbkine |
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