Human Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) ELISA Kit
| Product Name | Human Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) ELISA Kit |
|---|---|
| Description | NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. This assay has high sensitivity and excellent specificity for detection of Human NFATC1. No significant cross-reactivity or interference between Human NFATC1 and analogues was observed. |
| Synonyms | MGC138448, NF-ATC, NFAT2, NFATc, NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytosolic component 1 |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.115 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. |
| Supplier | Abebio |
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