Human Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) ELISA Kit
| Product Name | Human Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) ELISA Kit |
|---|---|
| Description | Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.æKCNN2æis a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene. This assay has high sensitivity and excellent specificity for detection of Human KCNN2. No significant cross-reactivity or interference between Human KCNN2 and analogues was observed. |
| Synonyms | KCa2.2, SK2, SKCA2, hSK2, apamin-sensitive small-conductance Ca2+-activated potassium channel|small conductance calcium-activated potassium channel protein 2 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.059 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.æKCNN2æis a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene. |
| Supplier | Abebio |
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