| Product Name | Human Prickle-like protein 2 (PRICKLE2) ELISA Kit |
|---|---|
| Description | By searching an EST database for sequences similar to those of Drosophila and Xenopus Prickle, Katoh and Katoh (2003) identified human PRICKLE2. The deduced 844-amino acid protein contains an N-terminal PET domain followed by 3 LIM domains and a C-terminal prickle homology domain. PRICKLE2 shares 51.9% overall identity with PRICKLE1 and 79.3% identity within the N-terminal PET and LIM domains. EST database analysis revealed that PRICKLE1 and PRICKLE2 are coexpressed in brain, eye, and testis; additionally, PRICKLE2 is expressed in fetal brain, adult cartilage, pancreatic islet, gastric cancer, and uterine tumor.Katoh and Katoh (2003) determined that the PRICKLE2 gene contains at least 8 exons and that the 5-prime untranslated region is interrupted by intron 1. This assay has high sensitivity and excellent specificity for detection of Human PRICKLE2. No significant cross-reactivity or interference between Human PRICKLE2 and analogues was observed. |
| Synonyms | DKFZp686D143, DKFZp686H1748, DKFZp686M031, prickle-like 2 |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | By searching an EST database for sequences similar to those of Drosophila and Xenopus Prickle, Katoh and Katoh (2003) identified human PRICKLE2. The deduced 844-amino acid protein contains an N-terminal PET domain followed by 3 LIM domains and a C-terminal prickle homology domain. PRICKLE2 shares 51.9% overall identity with PRICKLE1 and 79.3% identity within the N-terminal PET and LIM domains. EST database analysis revealed that PRICKLE1 and PRICKLE2 are coexpressed in brain, eye, and testis; additionally, PRICKLE2 is expressed in fetal brain, adult cartilage, pancreatic islet, gastric cancer, and uterine tumor.Katoh and Katoh (2003) determined that the PRICKLE2 gene contains at least 8 exons and that the 5-prime untranslated region is interrupted by intron 1. |
| Supplier | Abebio |
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