Human Putative potassium channel regulatory protein (KCNRG) ELISA Kit
| Product Name | Human Putative potassium channel regulatory protein (KCNRG) ELISA Kit |
|---|---|
| Description | KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K+ channels and inhibits their function. KCNRG has been found to be predominatly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent. Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis. This assay has high sensitivity and excellent specificity for detection of Human KCNRG. No significant cross-reactivity or interference between Human KCNRG and analogues was observed. |
| Synonyms | RP11-34F20.6, DLTET, |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.078 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K+ channels and inhibits their function. KCNRG has been found to be predominatly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent. Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis. |
| Supplier | Abebio |
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