| Product Name | Human Serine protease 27 (PRSS27) ELISA Kit |
|---|---|
| Description | Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue. The deduced 290-amino acid preproprotease contains an N-terminal signal peptide, followed by a prosequence and a 256-amino acid serine protease catalytic domain. The catalytic domain contains the essential catalytic triad (his75, asp124, and ser229) conserved in serine proteases, as well as 2 putative N-glycosylation sites. Northern blot analysis revealed expression of pancreasin only in pancreas. RT-PCR detected expression in several other tissues, including strong expression in lung and placenta. Immunocytochemical analysis of pancreatic carcinoma cells revealed cytoplasmic reactivity, and transfected Chinese hamster ovary cells secreted pancreasin into the medium. This assay has high sensitivity and excellent specificity for detection of Human PRSS27. No significant cross-reactivity or interference between Human PRSS27 and analogues was observed. |
| Synonyms | CAPH2, MPN, channel-activating protease 2|marapsin|pancreasin |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue. The deduced 290-amino acid preproprotease contains an N-terminal signal peptide, followed by a prosequence and a 256-amino acid serine protease catalytic domain. The catalytic domain contains the essential catalytic triad (his75, asp124, and ser229) conserved in serine proteases, as well as 2 putative N-glycosylation sites. Northern blot analysis revealed expression of pancreasin only in pancreas. RT-PCR detected expression in several other tissues, including strong expression in lung and placenta. Immunocytochemical analysis of pancreatic carcinoma cells revealed cytoplasmic reactivity, and transfected Chinese hamster ovary cells secreted pancreasin into the medium. |
| Supplier | Abebio |
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