Human Signal transducer and activator of transcription 1 (STAT1) ELISA Kit
| Product Name | Human Signal transducer and activator of transcription 1 (STAT1) ELISA Kit |
|---|---|
| Description | STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons. In response to IFN-gamma; stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-_ or IFN-_ stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic. This assay has high sensitivity and excellent specificity for detection of Human STAT1. No significant cross-reactivity or interference between Human STAT1 and analogues was observed. |
| Synonyms | DKFZp686B04100, ISGF-3, STAT91, OTTHUMP00000205845|signal transducer and activator of transcription 1|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p8 |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.059 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons. In response to IFN-gamma; stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-_ or IFN-_ stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic. |
| Supplier | Abebio |
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