| Product Name | IA-2/PTPRN Monoclonal Antibody |
|---|---|
| Description | IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker. |
| Synonyms | FLJ16131,IA 2/PTP,IA2,IA-2,ICA 512,ICA3,ICA512,Islet cell antigen 512,Islet cell autoantigen 3,PTP IA 2,PTPRN,R PTP N |
| Host | Mouse |
| Clone | 94 |
| Immunogen | Fusion protein of IA-2/PTPRN |
| Isotype | IgG3 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q16849 |
| Background | IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker. |
| Supplier | Elabscience |
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