| Product Name | IDR 1002 |
|---|---|
| Description |
IDR 1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR 1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR 1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signaling pathways. IDR 1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged withTLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged murine model of airway inflammation. |
| Synonyms | Innate defense regulator peptide 1002 |
| Molecular Weight | 1652.06 Da |
| Target | Antibacterials |
| Amino Acid Sequence | VQRWLIVWRIRK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1224095-25-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Nijnik (2010) Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 184(5) 2539 PMID: 20107187Wu et al (2017) Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model. J Immunol. 199(10) 3592 PMID: 28993516Piyadasa et al (2021) Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002. J Med Chem. 64(10) 6696 PMID: 33974425Sebők et al (2023) Modulation of the immune response by the host defense peptide IDR-1002 in chicken hepatic cell culture. Sci Rep. 13(1) 14530 PMID: 37666888 Related productsAll antimicrobial peptides >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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