| Product Name | IGSF8, 28-579aa, Human, Baculovirus |
|---|---|
| Description | IGSF8, also known as Immunoglobulin superfamily member 8, is a member of the immunoglobulin protein superfamily. It interact with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. Also, this protein may function as a tumor suppressor by inhibiting the proliferation of certain cancers. Recombinant human IGSF8 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Immunoglobulin superfamily member 8, IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL |
| Host | Virus |
| Molecular Weight |
32.6kDa (292aa) 28-40kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | ADLREVLVPE GPLYRVAGTA VSISCNVTGY EGPAQQNFEW FLYRPEAPDT ALGIVSTKDT QFSYAVFKSR VVAGEVQVQR LQGDAVVLKI ARLQAQDAGI YECHTPSTDT RYLGSYSGKV ELRVLPDVLQ VSAAPPGPRG RQAPTSPPRM TVHEGQELAL GCLARTSTQK HTHLAVSFGR SVPEAPVGRS TLQEVVGIRS DLAVEAGAPY AERLAAGELR LGKEGTDRYR MVVGGAQAGD AGTYHCTAAE WIQDPDGSWA QIAEKRAVLA HVDVQTLSSQ LAVTVGPGER RIGPGEPLEL LCNVSGALPP AGRHAAYSVG WEMAPAGAPG PGRLVAQLDT EGVGSLGPGY EGRHIAMEKV ASRTYRLRLE AARPGDAGTY RCLAKAYVRG SGTRLREAAS ARSRPLPVHV REEGVVLEAV AWLAGGTVYR GETASLLCNI SVRGGPPGLR LAASWWVERP EDGELSSVPA QLVGGVGQDG VAELGVRPGG GPVSVELVGP RSHRLRLHSL GPEDEGVYHC APSAWVQHAD YSWYQAGSAR SGPVTVYPYM HALDTHHHHH H |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol. |
| Concentration | 1mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Kolesnikova TV., et al, (2004) Blood. 103:3013-3019. Wang HX., et al, (2015) Cell Res. 25:370-385. |
| Background | IGSF8, also known as Immunoglobulin superfamily member 8, is a member of the immunoglobulin protein superfamily. It interact with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. Also, this protein may function as a tumor suppressor by inhibiting the proliferation of certain cancers. Recombinant human IGSF8 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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