| Product Name | IL-19 Monoclonal Antibody |
|---|---|
| Description | IL-19,a member of the IL-10 cytokine family,is expressed in epithelial cells,endothelial cells,and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes,which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS),and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders,such as breast cancer,squamous cell carcinoma of the skin,asthma,endotoxic shock,uremia,psoriasis,rheumatoid arthritis,and periodontal and vascular disease. |
| Synonyms | IL 10C,IL 19,IL19,interleukin 19,MDA1,NG.1,ZMDA1 |
| Host | Mouse |
| Clone | 257 |
| Immunogen | Fusion protein of IL-19 |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q9UHD0 |
| Background | IL-19,a member of the IL-10 cytokine family,is expressed in epithelial cells,endothelial cells,and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes,which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS),and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders,such as breast cancer,squamous cell carcinoma of the skin,asthma,endotoxic shock,uremia,psoriasis,rheumatoid arthritis,and periodontal and vascular disease. |
| Supplier | Elabscience |
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