| Product Name | IL17RA, 33-320aa, Human, Baculovirus |
|---|---|
| Description | IL17RA, also known as interleukin-17 receptor A isoform 1, is a cytokine receptor which binds interleukin 17. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. It is a type1 membrane glycoprotein that binds with low affinity to interleukin 17A. This protein and Interleukin 17A play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Recombinant human IL17RA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Interleukin-17 receptor A isoform 1, IL17RA, CANDF5, CD217, CDw217, hIL-17R, IL-17RA, IL17R, IMD51 |
| Host | Virus |
| Molecular Weight |
110.5kDa (987aa) 100-150KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLWVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH |
| Tag | hIgG-His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Honorati MC., et al, (2001) Rheumatology 40:522-527. Yao Z., et al, (1997) Cytokine 9:794-800. |
| Background | IL17RA, also known as interleukin-17 receptor A isoform 1, is a cytokine receptor which binds interleukin 17. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. It is a type1 membrane glycoprotein that binds with low affinity to interleukin 17A. This protein and Interleukin 17A play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Recombinant human IL17RA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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