| Product Name | IL1F10, 1-152aa, Human |
|---|---|
| Description | IL1F10 also known as interleukin-1 family member 10. IL1F10 is cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS) and ligand for IL-36R/IL1RL2. Recombinant human IL1F10 was expressed in E.coli and purified by using conventional chromatography techniques |
| Synonyms | Interleukin-1 family member 10, Interleukin-1 family member 10, FIL1-theta, FKSG75, IL1HY2, IL-38, IL1-theta, IL1HY2 |
| Host | E. coli |
| Molecular Weight | 43.7kDa (398aa) |
| Amino Acid Sequence | MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICTLPNRGL DRTKVPIFLG IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl Buffer (pH8.0) containing 10% glycerol |
| Concentration | 0.5mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Bensen J.T., et al. (2001) J. Interferon Cytokine Res. 21:899-904. van de Veerdonk F.L., et al. (2012) Proc. Natl. Acad. Sci. u.S.A. 109:3001-3005. |
| Background | IL1F10 also known as interleukin-1 family member 10. IL1F10 is cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS) and ligand for IL-36R/IL1RL2. Recombinant human IL1F10 was expressed in E.coli and purified by using conventional chromatography techniques |
| Supplier | ARP |
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