| Product Name | IL31, 24-159aa, Canine, Baculovirus |
|---|---|
| Description | IL31, also known as interleukin 31, is a member of the gp130/interleukin-6 cytokine family that is produced by cell types such as T helper 2 lymphocytes and cutaneous lymphocyte antigen positive skin homing T cells. IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. Recombinant canine IL31, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | interleukin 31, IL31, IL-31 |
| Host | Virus |
| Molecular Weight |
26.1kDa (231aa) 28-40KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | SHMAPTHQLP PSDVRKIILE LQPLSRGLLE DYQKKETGVP ESNRTLLLCL TSDSQPPRLN SSAILPYFRA IRPLSDKNII DKIIEQLDKL KFQHEPETEI SVPADTFECK SFILTILQQF SACLESVFKS LNSGPQHHHH HH |
| Tag | His-tag |
| Reactivity | Canine |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95 % by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | MizunoT., et al, (2009) Vet. Immunol. Immunopathol. 131:140-143. Gonzales AJ., et al, (2013) Vet. Dermatol. 24:48-53. |
| Background | IL31, also known as interleukin 31, is a member of the gp130/interleukin-6 cytokine family that is produced by cell types such as T helper 2 lymphocytes and cutaneous lymphocyte antigen positive skin homing T cells. IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. Recombinant canine IL31, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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