| Product Name | IL4, 25-153aa, Human (Bioactivity Validated) |
|---|---|
| Description | IL4, also known as Interleukin 4 isoform1, is a pleiotropic cytokine that has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of naive helper T-cell to Th2 cells. IL4 is a co-stimulator of DNA-synthesis and is induces the expression of class II MHC molecules on resting B-cells. It also enhances both secretion and cell surface expression of IgE and IgG1. Recombinant human IL4, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | Interleukin 4 isoform1, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, B cell growth factor 1, B cell IgG differentiation factor, B Cell Stimulatory Factor 1, B-cell stimulatory factor 1, BCGF 1, BCGF1, Binetrakin, BSF-1, BSF1, IGG1 induction factor, IL 4, IL-4, IL4, IL4_HUMAN, Il4e12, Interleukin 4, Interleukin 4 variant 2, Interleukin 4, isoform 1, Interleukin-4, Lymphocyte stimulatory factor 1, MGC79402, Pitrakinra |
| Host | E. coli |
| Molecular Weight |
46.4kDa (413aa) 28-57kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS |
| Reactivity | Mouse |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Van Kimmenade A., et al (1988). Eur J Biochem. 173(1): 109-14 Yokota T., et al (1986). Proc. Nati. Acad. Sci. USA. 83(16): 5894-8 |
| Background | IL4, also known as Interleukin 4 isoform1, is a pleiotropic cytokine that has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of naive helper T-cell to Th2 cells. IL4 is a co-stimulator of DNA-synthesis and is induces the expression of class II MHC molecules on resting B-cells. It also enhances both secretion and cell surface expression of IgE and IgG1. Recombinant human IL4, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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