| Product Name | Indolicidin |
|---|---|
| Description | Indolicidin is a 13 amino acid cationic cathelicidin family anti-microbial peptide (AMP) isolated from the cytoplasmic granules of bovine neutrophils. Indolicidin exhibits membrane permeabilization effects and antimicrobial activity against a wide spectrum of pathogens which include gram-positive and gram-negative bacteria, fungi, protozoa and the HIV-1 virus. Indolicidin is also an immune system modulator and an inhibitor of aminoglycoside antibiotic resistance enzymes. |
| Synonyms | 140896-21-5, AM-070, AM070, HIV-1 virus, ILPWKWPWWPWRR-NH2, Indolicidin, antimicrobial, cathelicidin, fungi, immune system modulator, membrane permeabilization, protozoa |
| Molecular Weight | 1906.3 Da |
| Target | Antibacterials,Antivirals,Antifungals |
| Amino Acid Sequence | ILPWKWPWWPWRR-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 140896-21-5 |
| Storage | Store desiccated and frozen in the dark |
| Notes | Modifications: C terminal amide |
| References |
Subbalakshmi and Sitaram (1998) Mechanism of antimicrobial action of indolicidin. FEMS Microbiol. Lett. 160(1) 91 PMID: 9495018Sitaram et al (2003) Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin. Biochem. Biophys. Res. Commun. 309(4) 879 PMID: 13679055Tsai et al (2009) Coupling Molecular Dynamics Simulations with Experiments for the Rational Design of Indolicidin-Analogous Antimicrobial Peptides. J. Mol. Biol. 392(3) 837 PMID: 19576903Nielsen and Lund R (2022) Molecular Transport and Growth of Lipid Vesicles Exposed to Antimicrobial Peptides. Langmuir 38(1) 374 PMID: 34902242 Related areas All antimicrobial peptides >All antifungal agents >All antiviral agents >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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