| Product Name | Interleukin-1 receptor type 1, 21-336aa, Human, Baculovirus |
|---|---|
| Description | IL1R1, also known as interleukin-1 receptor type 1, associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. It is an important mediator involved in many cytokine induced immune and inflammatory responses. Recombinant human IL1R1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 |
| Host | Virus |
| Molecular Weight |
19.5kDa (174aa) 28-40KDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKLEHH HHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Beaulieu LM., et al. (2014) Arterioscler. Thromb. Vasc. Biol. 34:(3)552-564. Moos V., et al. (2000) Arthritis Rheum. 43(11):2417-22. |
| Background | IL1R1, also known as interleukin-1 receptor type 1, associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. It is an important mediator involved in many cytokine induced immune and inflammatory responses. Recombinant human IL1R1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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