| Product Name | INVS Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to INVS |
| Synonyms | INVS antibody; INV antibody; NPHP2 antibody; Inversin antibody; Inversion of embryo turning homolog antibody; Nephrocystin-2 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Inversin protein (1-101AA) |
| Isotype | IgG |
| Target | INVS |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q9Y283 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). |
| Supplier | Cusabio |
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