| Product Name | IRAK4 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to IRAK4 |
| Synonyms | IL-1 receptor-associated kinase 4 antibody; Interleukin 1 receptor associated kinase 4 mutant form 1 antibody; Interleukin-1 receptor-associated kinase 4 antibody; Interleukin1 receptor associated kinase 4 antibody; IPD1 antibody; IRAK 4 antibody; IRAK-4 antibody; IRAK4 antibody; IRAK4 mutated form 1 antibody; IRAK4_HUMAN antibody; LOC 51135 antibody; NY REN 64 antibody; NY REN 64 antigen antibody; NY-REN-64 antibody; REN64 antibody; Renal carcinoma antigen NY-REN-64 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human Interleukin-1 receptor-associated kinase 4 protein (1-220AA) |
| Isotype | IgG |
| Target | IRAK4 |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | Q9NWZ3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. |
| Supplier | Cusabio |
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