| Product Name | IRBP (1-20) (human) |
|---|---|
| Description | IRBP (1-20) (human) is the 1 to 20 amino acid N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP, also known as retinol binding protein-3 (RBP-3), is a 1264 amino acid residue glycolipoprotein residing in the interphotoreceptor matrix where it is the major extracellular retinoid-binding protein. IRBP is often the target of autoimmune attack and this is one of the leading causes of uveitis. IRBP peptide (1-20) (human) contains a major epitope for the H-2b haplotype and immunization with IRBP (1–20) (human) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU), a widely used rodent model of human disease. |
| Synonyms | epitope, human interphotoreceptor retinoid binding protein, 298202-25-2, GPTHLFQPSLVLDMAKVLLD, H-GPTHLFQPSLVLDMAKVLLD-OH, IM-040, IM040, IRBP, IRBP (1-20) (human), experimental autoimmune uveoretinitis (EAU), immunology, uveitogenic |
| Molecular Weight | 2194.62 Da |
| Target | Epitopes |
| Amino Acid Sequence | GPTHLFQPSLVLDMAKVLLD |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 298202-25-2 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Avichezer et al (2000) Identification of a New Epitope of Human IRBP that Induces Autoimmune Uveoretinitis in Mice of the H-2b Haplotype. Invest. Ophthalmol. Vis. Sci. 41(1) 127 PMID: 10634611Fengqi et al (2009) Role of DAF in Protecting against T-Cell Autoreactivity that Leads to Experimental Autoimmune Uveitis. Invest. Ophthalmol. Vis. Sci. 50(8) 3778 PMID: 19443714Meng et al (2017) Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice. Cell Mol. Immunol. 14 702 PMID: 26996065 Related areasAll epitopes >All immunology research areas > |
| Supplier | Isca Biochemicals Limited |
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