| Product Name | ITM2C Monoclonal Antibody |
|---|---|
| Description | The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members,ITM2A and ITM2B. ITM2C,often called transmembrane protein BRI3,is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP,competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention. |
| Synonyms | BRICD2C,Cerebral protein 14,E25,E25C,integral membrane protein 2C,ITM2C,ITM3,PSEC0047,Transmembrane protein BRI3 |
| Host | Mouse |
| Clone | 654 |
| Immunogen | Fusion protein of ITM2C |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | ELISA, IF |
| Form | PBS with 0.1% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q9NQX7 |
| Background | The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members,ITM2A and ITM2B. ITM2C,often called transmembrane protein BRI3,is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP,competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention. |
| Supplier | Elabscience |
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