| Product Name | JIP2/IB2 Antibody: ATTO 565 |
|---|---|
| Description | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It is expressed mainly in the cerebellum, pituitary gland, occipital lobe, and the amygdala of the brain, but also in the pancreas, including insulin-secreting cells. Mouse Anti-Mouse JIP2/IB2 Monoclonal IgG1 |
| Synonyms | MAPK8IP2 Antibody, C jun amino terminal kinase interacting protein 2 Antibody, C-jun-amino-terminal kinase-interacting protein 2 Antibody, Homologous to mouse JIP 1 Antibody, IB 2 Antibody, IB-2 Antibody, IB2 Antibody, Islet brain 2 Antibody, Islet-brain- |
| Host | Mouse |
| Clone | S135-37 |
| Immunogen |
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2. Rat: 94% identity (127/135 amino acids identical). Human: 86% identity (173/200 amino acids identical) >50% identity with JIP-1. |
| Isotype | IgG1 |
| Specificity | Detects ~>100 kDa. Does not cross-react with JIP-1/IB-1. |
| Reactivity | Human, Mouse, Rat |
| Applications | ICC, IF, IHC, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Gene Id | NP_068740.3. 60597 |
| Uniprot | Q9ERE9 |
| Background | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It is expressed mainly in the cerebellum, pituitary gland, occipital lobe, and the amygdala of the brain, but also in the pancreas, including insulin-secreting cells. |
| Supplier | Stressmarq Biosciences |
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