| Product Name | KDEL Antibody: Streptavidin |
|---|---|
| Description | The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. Mouse Anti-KDEL Monoclonal IgG1 |
| Synonyms | KDEL Antibody, Lys Asp Glu Leu Antibody, Lys-Asp-Glu-Leu (KDEL) Antibody, Lys-Asp-Glu-Leu Antibody, Lysine-aspartic acid-glutamate-leucine Antibody |
| Host | Mouse |
| Clone | 2C1 |
| Immunogen | KDEL peptide (C-AVKDEL -COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA) |
| Isotype | IgG1 |
| Specificity | Detects KDEL tagged proteins. |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Background | The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. |
| Supplier | Stressmarq Biosciences |
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