| Product Name | Kemptide |
|---|---|
| Description | Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA). Kemptide is derived from a phosphorylation sequence of pig liver pyruvate kinase, a natural PKA substrate and is a phosphate acceptor peptide that when used as a synthetic substrate for PKA has a Km of 16 µM. Kemptide has kinetics comparable to native protein substrates. |
| Synonyms | pyruvate kinase, 65189-71-1, KS-030, KS030, Kemptide, LRRASLG, PKA, acceptor peptide, cAMP-dependent protein kinase, phosphate, phosphorylation, substrate |
| Molecular Weight | 771.9 Da |
| Target | Kinases |
| Amino Acid Sequence | LRRASLG |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 65189-71-1 |
| Storage | Store dark, frozen and desiccated |
| Notes | Modifications: None |
| References |
Giembycz and Diamond (1990) Evaluation of Kemptide, a synthetic serine containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues Biochem. Pharmacol. 39(2) 271 PMID: 2154228Galello et al (2010) Characterization of substrates that have a differential effect on Saccharomyces cerevisiae protein kinase A holoenzyme activation. J. Biol. Chem. 285(39) 29770 PMID: 20639203Mena-Ulecia et al (2014) Study of the Affinity between the Protein Kinase PKA and Peptide Substrates Derived from Kemptide Using Molecular Dynamics Simulations and MM/GBSA. PLoS ONE 9(10) e109639 PMID: 25275314PubChem - Kemptide Related areasAll kinases >All substrate peptides > |
| Supplier | Isca Biochemicals Limited |
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