| Product Name | Ki-67 Monoclonal Antibody |
|---|---|
| Description | Ki-67 is mainly used to determine the proliferation activity of cells, and are expressed in all the active cell cycles (G1, S, G2 and mitosis), but not expressed in the G0 period. Clinical data indicate that the level of Ki-67 proliferation index is closely related with the differentiation degree, metastasis and prognosis of many cancer. Thus, it is also one of the important reference index of the prognosis for some malignant tumors.Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). |
| Synonyms | Antigen Ki67,KI67,KIA,Marker of proliferation Ki-67,MIB ,PPP1R105,Proliferation marker protein Ki-67,Protein phosphatase 1 regulatory subunit 105 |
| Host | Mouse |
| Clone | PT0159 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of Ki-67 |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | P46013 |
| Background | Ki-67 is mainly used to determine the proliferation activity of cells, and are expressed in all the active cell cycles (G1, S, G2 and mitosis), but not expressed in the G0 period. Clinical data indicate that the level of Ki-67 proliferation index is closely related with the differentiation degree, metastasis and prognosis of many cancer. Thus, it is also one of the important reference index of the prognosis for some malignant tumors.Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). |
| Supplier | Elabscience |
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