| Product Name | KIR2DL3 (23-223aa), Human, Recombinant, Recombinant |
|---|---|
| Description | An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, cl-6, NKAT2 or KIR-K7), which recognizes class I MHC molecules(HLA-Cw1, -Cw3, -Cw7, and Cw8). The protein coding region of the extracellular domain of KIR2DL3 (22-223aa) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL3 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. |
| Synonyms | KIR2DL3, CD158B2, KIRCL23, NKAT2, KIR2DL3 (p58 KIR, CD158), MHC class I NK cell receptor, Natural killer-associated transcript 2, NKAT-2, NKAT2a, NKAT2b, p58 natural killer cell receptor clone CL-6, p58 NK receptor, p58.2 MHC class-I-specific NK re, Killer cell immunoglobulin-like receptor 2DL3, Killer cell immunoglobulin-like receptor 2DL3 CD158b, GL183, Killer Cell Immunoglobulin Like Receptor 2DL3, Killer inhibitory receptor CL2 3, KIR023GB, MHC Class I NK Cell Receptor, Natural Killer Associated Transcript 2, p58, p58 Natural Killer Cell Receptor Clone CL6, p58.2 MHC Class I Specific NK Receptor, |
| Host | E. coli |
| Molecular Weight | 13.0kDa (112aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGIS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GN |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate-buffered saline (pH 7.4) |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Steffens, U. et al. (1998) Tissue Antigens 51, 398-413. Wagtmann, N. R., et al. (1995) Immunity 2, 439-449. Colonna, M. et al. (1995) Science 268, 405-408. Kim, J. et al. (1997) J. Immunol. 159, 3875-3882 |
| Background | An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, cl-6, NKAT2 or KIR-K7), which recognizes class I MHC molecules(HLA-Cw1, -Cw3, -Cw7, and Cw8). The protein coding region of the extracellular domain of KIR2DL3 (22-223aa) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL3 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. |
| Supplier | ARP |
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