| Product Name | KIR2DL5A, 22-238aa, Human, Baculovirus |
|---|---|
| Description | KIR2DL5A, also known as killer cell immunoglobulin-like receptor 2DL5A, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. It is detected on the cell surface as a monomer that, upon tyrosine phosphorylation, recruits the Src homology region 2-containing protein tyrosine phosphatase-2, It is thus an inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that it plays a specialized role in innate immunity. Recombinant human KIR2DL5A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Killer cell immunoglobulin-like receptor 2DL5A, KIR2DL5A, CD158F, KIR2DL5A.1, KIR2DL5A.3 |
| Host | Virus |
| Molecular Weight |
123.6kDa (1104aa) 100-150kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | ADPHEGGQDK PLLSAWPSAV VPRGGHVTLL CRSRLGFTIF SLYKEDGVPV PELYNKIFWK SILMGPVTPA HAGTYRCRGS HPRSPIEWSA PSNPLVIVVT GLFGKPSLSA QPGPTVRTGE NVTLSCSSRS SFDMYHLSRE GRAHEPRLPA VPSVNGTFQA DFPLGPATHG GTYTCFGSLH DSPYEWSDPS DPLLVSVTGN SSSSSSSPTE PSSKTGIRRH VEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKHHHHHH |
| Tag | hIgG-His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Vilches, C., et al. (2000) J. Immunol. 164: 5797-5804. Lanier, L. L., et al. (2005) Rev. Immunol. 23: 187-225. |
| Background | KIR2DL5A, also known as killer cell immunoglobulin-like receptor 2DL5A, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. It is detected on the cell surface as a monomer that, upon tyrosine phosphorylation, recruits the Src homology region 2-containing protein tyrosine phosphatase-2, It is thus an inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that it plays a specialized role in innate immunity. Recombinant human KIR2DL5A, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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