| Product Name | KIR2DS4 (p50 KIR, CD158), Human, Recombinant, Recombinant |
|---|---|
| Description | An activating Killer Cell Ig-like Receptor(KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. The protein coding region of the extracellular domain of KIR2DS4(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DS4 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DS4 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. |
| Synonyms | KIR2DS4, CD158I, KKA3, NKAT8, KIR2DS4, p50 KIR, CD158, MHC class I NK cell receptor, Natural killer-associated transcript 8, NKAT-8, P58 natural killer cell receptor clone CL-39, p58 NK receptor, CL-17, CD158 antigen-like family member I, CD15, Killer cell immunoglobulin-like receptor 2DS4, Killer cell immunoglobulin-like receptor 2DS4, CD158 antigen like family member I, CD158i antigen, CL 17, CL 39, CL17, CL39, Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 4, Killer inhibitory receptor 4 1 2, KIR antigen 2DS4, KIR1D, KIR412, MGC120019, MGC125315, MGC125317, MHC class I NK cell receptor, Natural killer associated transcript 8, Natural killer cell inhibitory receptor, NKAT 8, P58 natural killer cell receptor clone CL 39, p58 NK receptor, |
| Host | E. coli |
| Molecular Weight | 15 kDa (134 aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris 8.0, 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Steffens U., et al. (1998) Tissue Antigens 51, 398-413. Wagtmann N., et al. (1995) Immunity. 2, 439-449. |
| Background | An activating Killer Cell Ig-like Receptor(KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. The protein coding region of the extracellular domain of KIR2DS4(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DS4 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DS4 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. |
| Supplier | ARP |
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