| Product Name | Kir6.1 Antibody |
|---|---|
| Description | Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4). . Mouse Anti-Rat Kir6.1 Monoclonal IgG2A |
| Synonyms | ATP-sensitive inward rectifier potassium channel 8 Antibody, Potassium channel inwardly rectifying subfamily J member 8 Antibody, uKATP-1 Antibody, Kcnj8 Antibody |
| Host | Mouse |
| Clone | S366-60 |
| Immunogen | Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1 |
| Isotype | IgG2a |
| Specificity | Detects ~45kDa. |
| Reactivity | Human, Mouse, Rat |
| Applications | ICC, IF, IHC, WB |
| Form | Purified, in PBS pH7.4, 50% glycerol, 0.1% sodium azide |
| Gene Id | NP_058795.3. 25472 |
| Uniprot | Q63664 |
| Background |
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4). |
| Supplier | Stressmarq Biosciences |
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