| Product Name | Kisspeptin 10 (human) |
|---|---|
| Description | Kisspeptin 10 (human) is a potent endogenous ligand for the kisspeptin receptor (KISS1, GPR54). Kisspeptin 10 (human) binds with high affinity to rat and human KISS1 receptors, with Ki values of 1.59 and 2.33 nM respectively. Kisspeptin 10 (human) has recently emerged as a key regulator of the mammalian reproductive axis while stimulation of GPR54 can also up-regulate proapoptotic genes which have tumour suppressor properties, inhibiting metastasis and invasion in mouse melanomas |
| Synonyms | Metastin (45-54) |
| Molecular Weight | 1302.5 Da |
| Target | Kisspeptin receptors |
| Amino Acid Sequence | YNWNSFGLRF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 374675-21-5 |
| Storage | Store frozen and desiccated in the dark |
| Notes | Modifications: Amide at C terminal |
| References |
Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677 PMID: 15596153Clarke et al (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and metabolism (Seoul, Korea) 30(2) 124 PMID: 26194072Guide to Pharmacology - Kisspeptin 10 (human) Related areas All peptides >All kisspeptin receptor modulators >All endocrinology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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