| Product Name | Kisspeptin 234 |
|---|---|
| Description |
Kisspeptin 234 is an analogue of kisspeptin 10 which acts as a kisspeptin receptor antagonist. Of a series, kisspeptin 234 most potently inhibited kisspeptin 10 stimulation of inositol phosphate release in Chinese hamster ovarian cells stably expressing the human GPR54 with an IC50 of 7 nM. Intracerebroventricular administration of kisspeptin 234 causes delayed vaginal opening in rats (an indicator of puberty) and prevents an increase in circulating luteinising hormone concentration when co-administrated with kisspeptin 10. |
| Synonyms | Peptide 234, p234, K234 |
| Molecular Weight | 1295.42 Da |
| Target | Kisspeptin receptors |
| Amino Acid Sequence | Ac-aNWNGFGwRF-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1145998-81-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-terminal acetyl, C-terminal amide; Ala-1 is D-Ala and Trp-8 is D-Trp |
| References |
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788Millar et al (2010) Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Res. 1364 81 PMID: 20858467lbers-Wolthers et al (2017) In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation. PLoS One 2(6) e0179156 PMID: 28650956Dinh et al (2023) The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Sci Rep. 13(1) 14046 PMID: 37640761 Related areasAll peptides >All kisspeptin receptor modulators >All endocrinology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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