| Product Name | KLK2, 25-261aa, Human, Baculovirus |
|---|---|
| Description | KLK2, also known as kallikerin-2 isoform1, is a secreted serine protease that is highly expressed in the human prostate gland. The enzyme is highly specific for cleavage after arginine residues. This protein is able to activate the urokinase-type plasminogen activator. It is inhibited by serpins such as protein C inhibitor, antichymotrypsin and plasminogen activator inhibitor. Recombinant human KLK2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Kallikerin-2 isoform1 , KLK2, hGK-1, hK2, KLK2A2, Glandular kallikrein 2 Glandular kallikrein-1, hGK 1, hGK-1, hK2, Kallikrein 2 prostatic, Kallikrein related peptidase 2, kallikrein, glandular, Kallikrein, prostatic, Kallikrein-2, KLK 2 Klk-2, Klk2, KLK2_HUMAN, KLK2A 2, KLK2A2 MGC12201, Tissue kallikrein 2, Tissue kallikrein-2 Ton |
| Host | Virus |
| Molecular Weight | 51kDa (454 aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | ADPIVGGWEC EKHSQPWQVA VYSHGWAHCG GVLVHPQWVL TAAHCLKKNS QVWLGRHNLF EPEDTGQRVP VSHSFPHPLY NMSLLKHQSL RPDEDSSHDL MLLRLSEPAK ITDVVKVLGL PTQEPALGTT CYASGWGSIE PEEFLRPRSL QCVSLHLLSN DMCARAYSEK VTEFMLCAGL WTGGKDTCGG DSGGPLVCNG VLQGITSWGP EPCALPEKPA VYTKVVHYRK WIKDTIAANP HHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT |
| Concentration | 1 mg/ml (determined by absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Frenette G., et al. (1997) Int J Cancer. 71:897-899. Mikolajczyk SD., et al. (1999) Cancer Res. 59:3927-3930. |
| Background | KLK2, also known as kallikerin-2 isoform1, is a secreted serine protease that is highly expressed in the human prostate gland. The enzyme is highly specific for cleavage after arginine residues. This protein is able to activate the urokinase-type plasminogen activator. It is inhibited by serpins such as protein C inhibitor, antichymotrypsin and plasminogen activator inhibitor. Recombinant human KLK2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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